Nasopharyngeal stenosis (NPS) is a pathologic narrowing within the nasopharynx caudal to the choanae (back of the nose) resulting in a variable degree of respiratory obstruction. This can occur as a congenital anomaly or be acquired, most commonly after vomiting/regurgitation post-anesthesia, after surgery, trauma, or due to a tumor. Traditional therapy involves surgery or serial balloon dilatation procedures. Balloon dilatation is minimally invasive and utilizes interventional technique, but can result in re-stricture in a few days to a few weeks. We have found that stenting of this nasopharyngeal region allows for a more permanent fixation and results in both dogs and cats have been extremely promising.
Case example: “Tyler” is an 11 year old domestic short hair cat who presented for the inability to breath through her nose and was in severe respiratory distress, needing admission to the emergency room for immediate oxygen therapy. Due to the location of the noise it was suspected that she had a narrowing in the back of her nasal passage (called the nasopharynx). She was subsequently anesthetized and an endoscope was used to evaluate the back of her nose. Scar tissue was seen, making a very small hole for her to be able to breath through (see pictures below). We utilized a balloon and a stent to open up this region permanently, and she was discharged only 8 hours later without any discomfort or pain. Two years later she is doing very well, breathing normally, acting as if nothing ever happened.
Nasopharyngeal stenosis (NPS) in a cat. (A) Retroflexed endoscopic image of stenotic nasopharynx. (B) Fluoroscopic-guided placement of hydrophilic guidewire through nares and across NPS lesion with balloon-expandable stent (BEMS) mounted on angioplasty balloon passed over guidewire. (C) Fluoroscopic image of BEMS partially inflated demonstrating stenotic lesion identified as balloon waist. (D) Fluoroscopic image following complete balloon inflation demonstrating effacement of stenotic area. (E) Fluoroscopic image following balloon deflation and removal, leaving BEMS expanded and in place across previously narrowed NPS.
Tracheal collapse is a progressive, degenerative disease of the cartilage rings in which hypocellularity and decreased glycosaminoglycan content leads to dynamic tracheal collapse during respiration. This is a condition of predominantly middle-age, small and toy-breed dogs which can present with signs ranging from a mild, intermittent “honking” cough to severe respiratory distress from dynamic upper-airway obstruction. Many of these animals are palliated with medications including anti-inflammatories, cough suppressants, and bronchodilators. Candidates for surgical therapy are those that have failed initial conservative medical management.
Various surgical techniques have been described however the currently recommended surgical therapy is extraluminal polypropylene prostheses. This technique involves placing extraluminal support rings around the trachea during an open cervical approach and has a reported 75%-85% overall success rate in 90 dogs for reducing clinical signs.15 This procedure is not without complications however. The same study reported that 5% of animals died peri-operatively, 11% developed laryngeal paralysis from the surgery, 19% required permanent tracheostomies, and 23% die of respiratory problems with a median survival of 25 months. More importantly, only 11% of the dogs in this study had intra-thoracic tracheal collapse (all dogs had extrathoracic tracheal collapse). The authors advised against this technique in animals with intra-thoracic tracheal collapse as the associated morbidity was unacceptably high.
Due to the relatively high morbidity associated with surgery, the use of intra-luminal stents has been investigated. A number of stents have been evaluated in the canine trachea, including both balloon-expandable (Palmaz), and self-expanding (Stainless steel, Laser-cut nitinol, Knitted nitinol) stents. Clinical improvement rates in 75%-90% of animals treated with self-expanding, intra-luminal stainless steel stents have been reported. Immediate complications were mostly minor although there was a peri-operative mortality rate of approximately 10%. Late complications included stent shortening, excessive granulation tissue, progressive tracheal collapse, and stent fracture.
The advantages of intra-luminal tracheal stenting include minimal invasiveness, avoiding dissection around the peri-tracheal neurovascular structures, shorter anesthesia times, and access to the entire intra-thoracic trachea. While most commonly performed under fluoroscopic guidance, some are now placing tracheal stents under endoscopic guidance. The search for a better intra-luminal tracheal stent continues and long-term studies will be necessary to determine late effects of these stents on the trachea and whether the progression of the tracheal collapse syndrome can be prevented or delayed through earlier intervention.
Idiopathic chylothorax is a frustrating disease to manage in which the pleural space fills with a chylous effusion resulting in dyspnea and sclerosing pleuritis over time if left untreated. Numerous surgical techniques have been described with varying success and invasiveness. Recently, thoracoscopic treatment has been described. Another less commonly considered technique is that used in humans which involves glue embolization of the thoracic duct using cyanoacrylate. This technique has been evaluated experimentally in animals as well as in a small number of clinical patients. This technique is performed under fluoroscopic guidance through an abdominal approach and involves performing lymphangiography with subsequent glue embolization of the cisterna chyli and thoracic duct. Glue embolization may be a viable primary therapy or follow-up treatment if a previous surgical attempt has failed.
Thoracic duct glue embolization for idiopathic chylothorax. (A) Contrast lymphangiogram through 22 gauge catheter surgically placed into efferent mesenteric lymphatic vessel demonstrating lymphatics, cisterna chyli and thoracic duct. (B) Radiograph post-glue embolization demonstrating thoracic duct branches filled with cyanoacrylate glue. Notice the many individual branches filled with this liquid mixture.
Tracheal foreign bodies are seemingly uncommon to encounter. When you do, having a fast, safe, and effective approach for retrieval is imperative. Most internists would use an endoscope and grasper or basket. In very small animals this requires extubation and a very small endoscope, which can result in hypoxia, hypercarbia and minimal or no ventilation. Using endoscopy with a retrieval basket, in conjunction with fluoroscopy, helps to guide you to the object and watch the wires entrap the prior to removing the basket. For radiolucent objects this would be done with endoscopy alone, but for radio-opaque material this can be easily done with a retrieval basket and fluoroscopy alone, directly through the endotracheal tube, preserving ventilation (see presentation) and foregoing the need for tracheoscopy.
The doctors of the Animal Medical Center saved my cat Sweepy's life and gave her another five wonderful years of life. This was my most dramatic experience with the AMC but neither my first nor last.
Daisy, my three year old guinea pig recently had surgery at the Animal Medical Center to remove an infected toe on her front foot. Dr. Quesenberry tried to save it with antibiotics, cream and bandages before having to perform surgery.
We adopted Shai through a foster family to discover she was mostly blind from abuse. Only months later, her retina detached and she became fully blind. This brave and small Shih Tzu still acclimated well, until she suffered a stroke. We came home to a normally snuggly pup who that day could not get up off of her side.
Kugel found us or we found Kugel only a few years ago - not sure how the story starts. But, since we first got Kugel she was very sick. The fabulous Dr. Kim Alexander helped us determine it was gastric lymphoma.
Thanks to Dr. Chick Weisse, Katie will turn 3 this October. Katie was diagnosed with a liver shunt at 3 months old. Dr. Weisse put her on medications till she was old enough to have the surgery correct her problem.
Read the 2013 UPDATE! Two years ago Sandy, my 10 year old Beagle began drinking excess amounts of water. Concerned, but not thinking it was life threatening, I brought her to my local vet. The doctor ran some blood tests. Then he told me it could be a sign of cancer.
Nico is our little bundle of Joy! He loves to play with his favorite squeaky toys, his best bud aka brother Tsember the German Shepherd, loves all the yummy treats he can get and can get super hyper with excitement; especially when you come home or when his bud Tsember comes over to play.
Today is my little Polly’s 9th birthday. Without AMCNY, she would not have this day. I got her when she 10 weeks old and deathly ill with pneumonia. We had been to several vets and many tried the usual treatments, to no avail.
In the early 1990s, I adopted a male tabby kitten, the runt of the litter. I named him Gypsy. He was a beautiful, playful little guy who drove my older cat crazy with his antics.
Hiro is our 3 year old cockapoo. When we got him neutered at 7 months, the vet we took him to accidentally cut his urethra. Once we learned of this accident the next day, we rushed Hiro to the AMC where reconstructive surgery was successfully performed!
My beautiful Brownnie was diagnosed with Cancer to her leg about two years ago. She went through radiation treatment and battled infections from time to time. However, her strength and will to continue living was so extraordinary, that she kept fighting until the last minute.
Our beloved bunny Chesney is currently undergoing treatment at the AMC for an intestinal blockage. Dr. Frohlich and Dr. Quesenberry decided to extend his treatment for an additional 24 hours, and we received the Christmas miracle we have been hoping for. Chesney will be home for the holidays!
In loving memory of my cat Doris - 10/2/1995 -11/22/2011. You're always in my heart.
Dr. Moore has taken care of our rabbit for many years. He has gone above and beyond what a doctor would do.
After a very brief illness our beloved Quaker Parrot (Anaid) of 12 years passed away, suddenly, yesterday (10/17/12). Our sincere Thanks and Appreciation to the Staff of AMC for their services.
Dear AMC, We just left the ER with our cat, Chatel, in a kitty coffin, and I did not remember to thank your staff, esp. our Vet, properly. I don't even recall our doctor's name, but it is important to me that she is properly commended for being so lovely, thoughtful, and caring through a sad event.
In loving memory of Zarina who passed away on August 18, 2011. Thanks for all those 16 years of happiness and joy.
This is a follow up to Nico's story posted here in 2010. After 17 years of providing unconditional love and companionship, Nico passed away on July 9, 2012.
Tabitha has been a part of my life for over 15 years... A wonderful tabby cat, with the beautiful markings and attitude.... reminding my dogs that she was here first and if she wished to be with me then they had to wait their turn.
I want to send a big thank you to Dr. Betsy Bond for giving us 14 1/2 years with our wonderful Westie named Christie.